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Clinical efficacy of arbekacin for Gram-negative bacteria.
Hamada, Yukihiro; Tamura, Kazuyoshi; Koyama, Ikumi; Kuroyama, Masakazu; Yago, Kazuo; Sunakawa, Keisuke.
Affiliation
  • Hamada Y; Department of Pharmacy, Kitasato East University Hospital, 2-1-1, Asamizodai, Minami-ku, Sagamihara, Kanagawa 252-0380, Japan. yuki@kitasato-u.ac.jp
J Infect Chemother ; 17(6): 876-9, 2011 Dec.
Article in En | MEDLINE | ID: mdl-21667069
ABSTRACT
In an analysis of methicillin-resistant Staphylococcus aureus (MRSA) infected patients treated with arbekacin (ABK) only, Gram-negative bacteria (GNB) that were inhibited by low minimal inhibitory concentrations (MICs) of amikacin (AMK) or gentamycin (GM) were eradicated by the end of the ABK treatment. On the other hand, GNB that were only inhibited by high MICs of AMK or GM persisted until the end of treatment with ABK only. Thus, ABK can be expected to be effective even in cases of mixed infection with GNB and MRSA.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Staphylococcal Infections / Dibekacin / Gram-Negative Bacterial Infections / Coinfection / Gram-Negative Bacteria / Anti-Bacterial Agents Limits: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: J Infect Chemother Journal subject: MICROBIOLOGIA / TERAPIA POR MEDICAMENTOS Year: 2011 Document type: Article Affiliation country: Japan
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Staphylococcal Infections / Dibekacin / Gram-Negative Bacterial Infections / Coinfection / Gram-Negative Bacteria / Anti-Bacterial Agents Limits: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: J Infect Chemother Journal subject: MICROBIOLOGIA / TERAPIA POR MEDICAMENTOS Year: 2011 Document type: Article Affiliation country: Japan