Neutralizing antibody response in the patients with hand, foot and mouth disease to enterovirus 71 and its clinical implications.
Virol J
; 8: 306, 2011 Jun 16.
Article
in En
| MEDLINE
| ID: mdl-21679417
ABSTRACT
Enterovirus 71 (EV71) has emerged as a significant pathogen causing large outbreaks in China for the past 3 years. Developing an EV71 vaccine is urgently needed to stop the spread of the disease; however, the adaptive immune response of humans to EV71 infection remains unclear. We examined the neutralizing antibody titers in HFMD patients and compared them to those of asymptomatic healthy children and young adults. We found that 80% of HFMD patients became positive for neutralizing antibodies against EV71 (GMT = 24.3) one day after the onset of illness. The antibody titers in the patients peaked two days (GMT = 79.5) after the illness appeared and were comparable to the level of adults (GMT = 45.2). Noticeably, the antibody response was not correlated with disease severity, suggesting that cellular immune response, besides neutralizing antibodies, could play critical role in controlling the outcome of EV71 infection in humans.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Enterovirus A, Human
/
Antibodies, Neutralizing
/
Hand, Foot and Mouth Disease
/
Antibodies, Viral
Limits:
Adult
/
Child, preschool
/
Humans
/
Infant
Country/Region as subject:
Asia
Language:
En
Journal:
Virol J
Journal subject:
VIROLOGIA
Year:
2011
Document type:
Article