The munc13-4-rab27 complex is specifically required for tethering secretory lysosomes at the plasma membrane.

Elstak, Edo D; Neeft, Maaike; Nehme, Nadine T; Voortman, Jarno; Cheung, Marc; Goodarzifard, Monireh; Gerritsen, Hans C; van Bergen En Henegouwen, Paul M P; Callebaut, Isabelle; de Saint Basile, Geneviève; van der Sluijs, Peter

Elstak, Edo D; Neeft, Maaike; Nehme, Nadine T; Voortman, Jarno; Cheung, Marc; Goodarzifard, Monireh; Gerritsen, Hans C; van Bergen En Henegouwen, Paul M P; Callebaut, Isabelle; de Saint Basile, Geneviève; van der Sluijs, Peter.

Affiliation

Elstak ED; Department of Cell Biology, University Medical Center Utrecht, Utrecht, The Netherlands.

Blood ; 118(6): 1570-8, 2011 Aug 11.

Article in En | MEDLINE | ID: mdl-21693760

Subject(s)

Lysosomes/metabolism; Membrane Proteins/metabolism; rab GTP-Binding Proteins/metabolism; Amino Acid Sequence; Animals; Binding Sites/genetics; COS Cells; Cell Line, Tumor; Chlorocebus aethiops; Exocytosis; HEK293 Cells; Humans; Luminescent Proteins/genetics; Luminescent Proteins/metabolism; Lymphohistiocytosis, Hemophagocytic/genetics; Lymphohistiocytosis, Hemophagocytic/metabolism; Lymphohistiocytosis, Hemophagocytic/pathology; Lysosomal-Associated Membrane Protein 1/metabolism; Membrane Proteins/chemistry; Membrane Proteins/genetics; Microscopy, Confocal; Microscopy, Fluorescence; Molecular Sequence Data; Multiprotein Complexes/metabolism; Mutation; Protein Binding; Sequence Homology, Amino Acid; T-Lymphocytes, Cytotoxic/metabolism; rab GTP-Binding Proteins/genetics; rab27 GTP-Binding Proteins

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Rab GTP-Binding Proteins / Lysosomes / Membrane Proteins Limits: Animals / Humans Language: En Journal: Blood Year: 2011 Document type: Article Affiliation country: Netherlands

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google