Preliminary study of letrozole use for improving spermatogenesis in non-obstructive azoospermia patients with normal serum FSH.
Asian J Androl
; 13(6): 895-7, 2011 Nov.
Article
in En
| MEDLINE
| ID: mdl-21706040
ABSTRACT
We investigated whether letrozole (2.5 mg day(-1)) improves sperm count in non-obstructive azoospermia (NOA) patients. Four men were included in this study, and they had folliculo-stimulating hormone and other hormone levels within the normal range and no varicoceles or chromosomal aberrations. These four patients were administered letrozole for 3 months. Sperm count, testicular volume, gonadotropin, testosterone (T) and estradiol (E2) blood levels were assessed before, during and 1 week after the suspension of treatment. All patients showed spermatozoa in their ejaculate, increased gonadotropin and T levels and lower E2 levels (P<0.05 in all cases), when letrozole was administered. This suggests that letrozole treatment might improve sperm count in an NOA sub-population; however, more studies, including the proper controls, are needed to confirm its efficacy.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Spermatogenesis
/
Triazoles
/
Aromatase Inhibitors
/
Azoospermia
/
Follicle Stimulating Hormone
/
Nitriles
Limits:
Humans
/
Male
Language:
En
Journal:
Asian J Androl
Journal subject:
MEDICINA REPRODUTIVA
/
UROLOGIA
Year:
2011
Document type:
Article
Affiliation country:
Italy