Methylator phenotype of malignant germ cell tumours in children identifies strong candidates for chemotherapy resistance.

Jeyapalan, J N; Noor, D A Mohamed; Lee, S-H; Tan, C L; Appleby, V A; Kilday, J P; Palmer, R D; Schwalbe, E C; Clifford, S C; Walker, D A; Murray, M J; Coleman, N; Nicholson, J C; Scotting, P J

Jeyapalan, J N; Noor, D A Mohamed; Lee, S-H; Tan, C L; Appleby, V A; Kilday, J P; Palmer, R D; Schwalbe, E C; Clifford, S C; Walker, D A; Murray, M J; Coleman, N; Nicholson, J C; Scotting, P J.

Affiliation

Jeyapalan JN; Children's Brain Tumour Research Centre, Centre for Genetics and Genomics, University of Nottingham, Queen's Medical Centre, Nottingham NG7 2UH, UK.

Br J Cancer ; 105(4): 575-85, 2011 Aug 09.

Article in En | MEDLINE | ID: mdl-21712824

Subject(s)

Caspase 8/metabolism; DNA (Cytosine-5-)-Methyltransferases/metabolism; DNA Methylation; Gene Silencing; Genes, Tumor Suppressor; Neoplasms, Germ Cell and Embryonal/drug therapy; Neoplasms, Germ Cell and Embryonal/genetics; Apoptosis; Child; Child, Preschool; Cluster Analysis; Drug Resistance, Neoplasm; Endodermal Sinus Tumor/drug therapy; Endodermal Sinus Tumor/genetics; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Germinoma/drug therapy; Germinoma/genetics; Humans; Male; Microarray Analysis; Neoplasms, Germ Cell and Embryonal/pathology; Phenotype; Polymerase Chain Reaction; Reproducibility of Results; Reverse Transcriptase Polymerase Chain Reaction; DNA Methyltransferase 3B

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Genes, Tumor Suppressor / Neoplasms, Germ Cell and Embryonal / DNA Methylation / Gene Silencing / DNA (Cytosine-5-)-Methyltransferases / Caspase 8 Type of study: Prognostic_studies Limits: Child / Child, preschool / Female / Humans / Male Language: En Journal: Br J Cancer Year: 2011 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom

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