[Impact of techniques for gastrointestinal tract reconstruction following gastrectomy on pancreatic ß-cell function in patients with type 2 diabetes mellitus].
Zhonghua Wei Chang Wai Ke Za Zhi
; 14(6): 415-8, 2011 Jun.
Article
in Zh
| MEDLINE
| ID: mdl-21713698
ABSTRACT
OBJECTIVE:
To evaluate the impact of different techniques for gastrointestinal tract reconstruction on postoperative pancreatic ß-cell function in patients with type 2 diabetes mellitus (T2DM).METHODS:
Twenty-three patients with gastric cancer and T2DM were studied. Techniques for reconstruction included Billroth I (n=13) and bypass procedures(Billroth II n=4 and Roux-en-Y anastomosis n=6). Pancreatic ß-cell function was evaluated by oral glucose tolerance test (OGTT). Serum insulin was measured by electrochemiluminescence immunoassay and blood glucose by glucose oxidase method. HOMA-IR and HOMA-ß were assessed.RESULTS:
T2DM remission rate was 90% (9/10) in the bypass group, and 23% (3/13) in Billroth I group (P<0.01). Glycosylated hemoglobin A1c and glycated hemoglobin HbA1 were improved significantly in patients after bypass procedures(P<0.05), but the difference in Billroth I group was not statistically significant (P>0.05). OGTT showed that fasting and post-glucose load plasma glucose at each time point were significantly lower in the bypass group compared to the Billroth I group. At 30 minutes and 60 minutes after glucose load, insulin levels and insulin release index were significantly higher in the bypass group compared to Billroth I( group, as were levels of HOMA-ß and ΔI30/ΔG30 in the bypass group(P<0.05).CONCLUSION:
Gastrointestinal bypass following gastrectomy may induce resolution of T2DM and improve ß-cells function.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Gastroenterostomy
/
Diabetes Mellitus, Type 2
/
Insulin-Secreting Cells
Type of study:
Observational_studies
/
Risk_factors_studies
Limits:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
Zh
Journal:
Zhonghua Wei Chang Wai Ke Za Zhi
Journal subject:
GASTROENTEROLOGIA
Year:
2011
Document type:
Article
Affiliation country:
China