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In vivo iron quantification in collagenase-induced microbleeds in rat brain.
McAuley, Grant; Schrag, Matthew; Barnes, Samuel; Obenaus, Andre; Dickson, April; Kirsch, Wolff.
Affiliation
  • McAuley G; Neurosurgery Center for Research, Training and Education, Loma Linda University, Loma Linda, California 92354, USA.
Magn Reson Med ; 67(3): 711-7, 2012 Mar.
Article in En | MEDLINE | ID: mdl-21721041
Brain microbleeds (BMB) are associated with chronic and acute cerebrovascular disease. Because BMB present in the brain is a source of potentially cytotoxic iron proportional to the volume of extravasated blood, BMB iron content is a potentially valuable biomarker both to assess tissue risk and small cerebral vessel health. We recently reported methods to quantify focal iron sources using phase images that were tested in phantoms and BMB in postmortem tissue. In this study, we applied our methods to small hemorrhagic lesions induced in the in vivo rat brain using bacterial collagenase. As expected by theory, measurements of geometric features in phase images correlated with lesion iron content measured by graphite furnace atomic absorption spectrometry. Iron content estimation following BMB in an in vivo rodent model could shed light on the role and temporal evolution of iron-mediated tissue damage and efficacy of potential treatments in cerebrovascular diseases associated with BMB.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain / Magnetic Resonance Imaging / Intracranial Hemorrhages / Iron Limits: Animals Language: En Journal: Magn Reson Med Journal subject: DIAGNOSTICO POR IMAGEM Year: 2012 Document type: Article Affiliation country: United States Country of publication: United States

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain / Magnetic Resonance Imaging / Intracranial Hemorrhages / Iron Limits: Animals Language: En Journal: Magn Reson Med Journal subject: DIAGNOSTICO POR IMAGEM Year: 2012 Document type: Article Affiliation country: United States Country of publication: United States