Disruption of the mouse protein tyrosine kinase 6 gene prevents STAT3 activation and confers resistance to azoxymethane.

Gierut, Jessica; Zheng, Yu; Bie, Wenjun; Carroll, Robert E; Ball-Kell, Susan; Haegebarth, Andrea; Tyner, Angela L

Gierut, Jessica; Zheng, Yu; Bie, Wenjun; Carroll, Robert E; Ball-Kell, Susan; Haegebarth, Andrea; Tyner, Angela L.

Affiliation

Gierut J; Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, Illinois 60607, USA.

Gastroenterology ; 141(4): 1371-80, 1380.e1-2, 2011 Oct.

Article in En | MEDLINE | ID: mdl-21741923

Subject(s)

Aberrant Crypt Foci/prevention & control; Azoxymethane; Carcinogens; Colon/enzymology; Colonic Neoplasms/prevention & control; STAT3 Transcription Factor/metabolism; src-Family Kinases/deficiency; Aberrant Crypt Foci/enzymology; Aberrant Crypt Foci/genetics; Aberrant Crypt Foci/pathology; Animals; Apoptosis; Cell Proliferation; Colon/pathology; Colonic Neoplasms/chemically induced; Colonic Neoplasms/enzymology; Colonic Neoplasms/genetics; Colonic Neoplasms/pathology; Dextran Sulfate; Disease Models, Animal; HCT116 Cells; Humans; Immunoblotting; Immunohistochemistry; Mice; Mice, Knockout; Neoplasm Proteins/genetics; Neoplasm Proteins/metabolism; Phosphorylation; Protein-Tyrosine Kinases/genetics; Protein-Tyrosine Kinases/metabolism; RNA Interference; STAT3 Transcription Factor/genetics; Signal Transduction; Time Factors; src-Family Kinases/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Azoxymethane / Carcinogens / Colon / Colonic Neoplasms / Src-Family Kinases / STAT3 Transcription Factor / Aberrant Crypt Foci Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Gastroenterology Year: 2011 Document type: Article Affiliation country: United States Country of publication: United States

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