Antitumour efficacy of MEK inhibitors in human lung cancer cells and their derivatives with acquired resistance to different tyrosine kinase inhibitors.

Morgillo, F; Cascone, T; D'Aiuto, E; Martinelli, E; Troiani, T; Saintigny, P; De Palma, R; Heymach, J V; Berrino, L; Tuccillo, C; Ciardiello, F

Morgillo, F; Cascone, T; D'Aiuto, E; Martinelli, E; Troiani, T; Saintigny, P; De Palma, R; Heymach, J V; Berrino, L; Tuccillo, C; Ciardiello, F.

Affiliation

Morgillo F; Sezioni di Oncologia Medica, Seconda Università degli Studi di Napoli, Via S. Pansini 5, Naples 80131, Italy.

Br J Cancer ; 105(3): 382-92, 2011 Jul 26.

Article in En | MEDLINE | ID: mdl-21750552

Subject(s)

Adenocarcinoma/drug therapy; Drug Resistance, Neoplasm; Lung Neoplasms/drug therapy; MAP Kinase Kinase Kinases/antagonists & inhibitors; Protein Kinase Inhibitors/therapeutic use; Adenocarcinoma of Lung; Animals; Benzenesulfonates/pharmacology; Cell Line, Tumor; Cell Proliferation/drug effects; Epithelial-Mesenchymal Transition/drug effects; Erlotinib Hydrochloride; Gefitinib; Gene Expression Profiling; Humans; Mice; Mice, Nude; Niacinamide/analogs & derivatives; Phenylurea Compounds; Piperidines/pharmacology; Pyridines/pharmacology; Quinazolines/pharmacology; Sorafenib; Xenograft Model Antitumor Assays

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Adenocarcinoma / Drug Resistance, Neoplasm / MAP Kinase Kinase Kinases / Protein Kinase Inhibitors / Lung Neoplasms Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Br J Cancer Year: 2011 Document type: Article Affiliation country: Italy Country of publication: United kingdom

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