Microenvironmental influence on pre-clinical activity of polo-like kinase inhibition in multiple myeloma: implications for clinical translation.

McMillin, Douglas W; Delmore, Jake; Negri, Joseph; Ooi, Melissa; Klippel, Steffen; Miduturu, Chandrasekhar V; Gray, Nathanael S; Richardson, Paul G; Anderson, Kenneth C; Kung, Andrew L; Mitsiades, Constantine S

McMillin, Douglas W; Delmore, Jake; Negri, Joseph; Ooi, Melissa; Klippel, Steffen; Miduturu, Chandrasekhar V; Gray, Nathanael S; Richardson, Paul G; Anderson, Kenneth C; Kung, Andrew L; Mitsiades, Constantine S.

Affiliation

McMillin DW; Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America.

PLoS One ; 6(7): e20226, 2011.

Article in En | MEDLINE | ID: mdl-21750699

Subject(s)

Cell Cycle Proteins/antagonists & inhibitors; Multiple Myeloma/drug therapy; Protein Serine-Threonine Kinases/antagonists & inhibitors; Proto-Oncogene Proteins/antagonists & inhibitors; Pteridines/pharmacology; Xenograft Model Antitumor Assays; Blotting, Western; Bone and Bones/drug effects; Bone and Bones/pathology; Caspase 3/metabolism; Cell Cycle/drug effects; Cell Cycle Proteins/metabolism; Cell Line; Cell Line, Tumor; Cell Survival/drug effects; Coculture Techniques; Dose-Response Relationship, Drug; Humans; Inhibitory Concentration 50; Multiple Myeloma/metabolism; Multiple Myeloma/pathology; Osteoclasts/drug effects; Poly(ADP-ribose) Polymerases/metabolism; Protein Serine-Threonine Kinases/metabolism; Proto-Oncogene Proteins/metabolism; Stromal Cells/drug effects; Time Factors; Tumor Burden/drug effects; Tumor Microenvironment/drug effects; Polo-Like Kinase 1

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pteridines / Proto-Oncogene Proteins / Protein Serine-Threonine Kinases / Cell Cycle Proteins / Xenograft Model Antitumor Assays / Multiple Myeloma Type of study: Prognostic_studies Limits: Humans Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2011 Document type: Article Affiliation country: United States Country of publication: United States

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