Resistance to the CCR5 inhibitor 5P12-RANTES requires a difficult evolution from CCR5 to CXCR4 coreceptor use.

Nedellec, Rebecca; Coetzer, Mia; Lederman, Michael M; Offord, Robin E; Hartley, Oliver; Mosier, Donald E

Nedellec, Rebecca; Coetzer, Mia; Lederman, Michael M; Offord, Robin E; Hartley, Oliver; Mosier, Donald E.

Affiliation

Nedellec R; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America.

PLoS One ; 6(7): e22020, 2011.

Article in En | MEDLINE | ID: mdl-21760945

Subject(s)

CCR5 Receptor Antagonists; Chemokines, CC/pharmacology; Directed Molecular Evolution; Drug Resistance, Viral/drug effects; Receptors, CCR5/metabolism; Receptors, CXCR4/metabolism; Amino Acid Sequence; Cyclohexanes/pharmacology; HIV Envelope Protein gp160/metabolism; HIV-1/drug effects; HIV-1/physiology; Humans; Maraviroc; Molecular Sequence Data; Receptors, CCR5/chemistry; Receptors, CXCR4/chemistry; Triazoles/pharmacology; Virus Replication/drug effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Directed Molecular Evolution / Receptors, CCR5 / Receptors, CXCR4 / Chemokines, CC / Drug Resistance, Viral / CCR5 Receptor Antagonists Limits: Humans Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2011 Document type: Article Affiliation country: United States

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