Design, synthesis, and biological evaluation of diminutive forms of (+)-spongistatin 1: lessons learned.

Smith, Amos B; Risatti, Christina A; Atasoylu, Onur; Bennett, Clay S; Liu, Junke; Cheng, Hongsheng; TenDyke, Karen; Xu, Qunli

Smith, Amos B; Risatti, Christina A; Atasoylu, Onur; Bennett, Clay S; Liu, Junke; Cheng, Hongsheng; TenDyke, Karen; Xu, Qunli.

Affiliation

Smith AB; Monell Chemical Senses Center and Laboratory for Research on the Structure of Matter, Department of Chemistry, University of Pennsylvania , Philadelphia, 19104, United States. smithab@sas.upenn.edu

J Am Chem Soc ; 133(35): 14042-53, 2011 Sep 07.

Article in En | MEDLINE | ID: mdl-21761891

Subject(s)

Macrolides/chemistry; Macrolides/pharmacology; Tubulin Modulators/chemistry; Tubulin Modulators/pharmacology; Animals; Cell Line, Tumor; Cell Proliferation/drug effects; Drug Design; Humans; Macrolides/chemical synthesis; Mice; Models, Molecular; Neoplasms/drug therapy; Tubulin Modulators/chemical synthesis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Macrolides / Tubulin Modulators Limits: Animals / Humans Language: En Journal: J Am Chem Soc Year: 2011 Document type: Article Affiliation country: United States Country of publication: United States

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