Development of a new permeability assay using low-efflux MDCKII cells.

Di, Li; Whitney-Pickett, Carrie; Umland, John P; Zhang, Hui; Zhang, Xun; Gebhard, David F; Lai, Yurong; Federico, James J; Davidson, Ralph E; Smith, Russ; Reyner, Eric L; Lee, Caroline; Feng, Bo; Rotter, Charles; Varma, Manthena V; Kempshall, Sarah; Fenner, Katherine; El-Kattan, Ayman F; Liston, Theodore E; Troutman, Matthew D

Di, Li; Whitney-Pickett, Carrie; Umland, John P; Zhang, Hui; Zhang, Xun; Gebhard, David F; Lai, Yurong; Federico, James J; Davidson, Ralph E; Smith, Russ; Reyner, Eric L; Lee, Caroline; Feng, Bo; Rotter, Charles; Varma, Manthena V; Kempshall, Sarah; Fenner, Katherine; El-Kattan, Ayman F; Liston, Theodore E; Troutman, Matthew D.

Affiliation

Di L; Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc., Groton, Connecticut, USA. li.di@pfizer.com

J Pharm Sci ; 100(11): 4974-85, 2011 Nov.

Article in En | MEDLINE | ID: mdl-21766308

Subject(s)

Permeability; ATP Binding Cassette Transporter, Subfamily B, Member 1/physiology; Animals; Cell Line; Cell Separation; Chromatography, Liquid; Dogs; Flow Cytometry; Humans; Intestinal Absorption; Real-Time Polymerase Chain Reaction; Tandem Mass Spectrometry

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Permeability Limits: Animals / Humans Language: En Journal: J Pharm Sci Year: 2011 Document type: Article Affiliation country: United States Country of publication: United States

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