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High expression of TGF-ß1 in the vaginal incisional margin predicts poor prognosis in patients with stage Ib-IIa cervical squamous cell carcinoma.
Fan, Dong-Mei; Wang, Xin-Jun; He, Tao; Wang, Yan; Zhou, Dan; Kong, Guo-Qiang; Jiang, Tao; Zhang, Mei-Mei.
Affiliation
  • Fan DM; The Department of Gynecology, The First Affiliated Hospital of Henan University of Science and Technology, Jinghua Road, Luoyang, 471003, Henan, China. fandmhnst@sina.cn
Mol Biol Rep ; 39(4): 3925-31, 2012 Apr.
Article in En | MEDLINE | ID: mdl-21773949
ABSTRACT
This study evaluated the relationship between altered cytoplasmic expression of TGF-ß1 in tissues of the vaginal incisional margin and vaginal cancer recurrence in patients with stage Ib-IIa cervical squamous cell carcinoma (CSCC). This paper also discusses the prognostic value of TGF-ß1 expression at these locations. We found that TGF-ß1 expression in the vaginal margin had a close association with vaginal recurrence of stage Ib-IIa CSCC and was an independent prognostic marker of this disease.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Vagina / Carcinoma, Squamous Cell / Uterine Cervical Neoplasms / Transforming Growth Factor beta1 Type of study: Prognostic_studies / Risk_factors_studies Limits: Adult / Aged / Female / Humans / Middle aged Language: En Journal: Mol Biol Rep Year: 2012 Document type: Article Affiliation country: China
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Vagina / Carcinoma, Squamous Cell / Uterine Cervical Neoplasms / Transforming Growth Factor beta1 Type of study: Prognostic_studies / Risk_factors_studies Limits: Adult / Aged / Female / Humans / Middle aged Language: En Journal: Mol Biol Rep Year: 2012 Document type: Article Affiliation country: China