Structure-function analysis of Friedreich's ataxia mutants reveals determinants of frataxin binding and activation of the Fe-S assembly complex.

Bridwell-Rabb, Jennifer; Winn, Andrew M; Barondeau, David P

Bridwell-Rabb, Jennifer; Winn, Andrew M; Barondeau, David P.

Affiliation

Bridwell-Rabb J; Department of Chemistry, Texas A&M University, College Station, Texas 77842, USA.

Biochemistry ; 50(33): 7265-74, 2011 Aug 23.

Article in En | MEDLINE | ID: mdl-21776984

Subject(s)

Friedreich Ataxia/metabolism; Iron-Binding Proteins/chemistry; Iron-Binding Proteins/metabolism; Iron-Sulfur Proteins/metabolism; Mutant Proteins/metabolism; Mutation, Missense/genetics; Sulfides/metabolism; Allosteric Regulation; Carbon-Sulfur Lyases/genetics; Carbon-Sulfur Lyases/metabolism; Crystallography, X-Ray; Enzyme Activation; Friedreich Ataxia/genetics; Humans; Iron-Binding Proteins/genetics; Iron-Regulatory Proteins/metabolism; Iron-Sulfur Proteins/genetics; Kinetics; Models, Molecular; Mutant Proteins/genetics; Protein Binding; Protein Conformation; Structure-Activity Relationship; Frataxin

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfides / Friedreich Ataxia / Mutation, Missense / Iron-Binding Proteins / Mutant Proteins / Iron-Sulfur Proteins Type of study: Prognostic_studies Limits: Humans Language: En Journal: Biochemistry Year: 2011 Document type: Article Affiliation country: United States Country of publication: United States

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