Lipid and sulfur substituted prenylcysteine analogs as human Icmt inhibitors.

Bergman, Joel A; Hahne, Kalub; Hrycyna, Christine A; Gibbs, Richard A

Bergman, Joel A; Hahne, Kalub; Hrycyna, Christine A; Gibbs, Richard A.

Affiliation

Bergman JA; Department of Medicinal Chemistry and Molecular Pharmacology and Purdue University Center for Cancer Research, Purdue University, West Lafayette, IN 47907, USA.

Bioorg Med Chem Lett ; 21(18): 5616-9, 2011 Sep 15.

Article in En | MEDLINE | ID: mdl-21782433

Subject(s)

Cysteine/analogs & derivatives; Enzyme Inhibitors/pharmacology; Lipids/chemistry; Protein Methyltransferases/antagonists & inhibitors; Sulfur/chemistry; Cysteine/chemical synthesis; Cysteine/chemistry; Cysteine/pharmacology; Dose-Response Relationship, Drug; Enzyme Inhibitors/chemical synthesis; Enzyme Inhibitors/chemistry; Humans; Molecular Structure; Protein Methyltransferases/metabolism; Stereoisomerism; Structure-Activity Relationship

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Methyltransferases / Sulfur / Cysteine / Enzyme Inhibitors / Lipids Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2011 Document type: Article Affiliation country: United States Country of publication: United kingdom

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