Conformational regulation of urokinase receptor function: impact of receptor occupancy and epitope-mapped monoclonal antibodies on lamellipodia induction.

Gårdsvoll, Henrik; Jacobsen, Benedikte; Kriegbaum, Mette C; Behrendt, Niels; Engelholm, Lars; Østergaard, Søren; Ploug, Michael

Gårdsvoll, Henrik; Jacobsen, Benedikte; Kriegbaum, Mette C; Behrendt, Niels; Engelholm, Lars; Østergaard, Søren; Ploug, Michael.

Affiliation

Gårdsvoll H; Finsen Laboratory, Rigshospitalet Section 3735, Copenhagen Biocenter, Ole Maaløes Vej 5, DK-2200 Copenhagen N, Denmark.

J Biol Chem ; 286(38): 33544-56, 2011 Sep 23.

Article in En | MEDLINE | ID: mdl-21799009

Subject(s)

Antibodies, Monoclonal/immunology; Epitope Mapping; Pseudopodia/metabolism; Receptors, Urokinase Plasminogen Activator/chemistry; Receptors, Urokinase Plasminogen Activator/metabolism; Amino Acid Sequence; Animals; Cell Line; Drosophila melanogaster; Humans; Inhibitory Concentration 50; Kinetics; Ligands; Mice; Models, Molecular; Molecular Sequence Data; Molecular Weight; Peptides/chemistry; Peptides/metabolism; Protein Structure, Secondary; Protein Structure, Tertiary; Pseudopodia/drug effects; Structure-Activity Relationship; Transfection; Urokinase-Type Plasminogen Activator/chemistry; Vitronectin/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pseudopodia / Epitope Mapping / Receptors, Urokinase Plasminogen Activator / Antibodies, Monoclonal Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2011 Document type: Article Affiliation country: Denmark Country of publication: United States

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