Development of a flow cytometric assay for detection of coated platelets in dogs and evaluation of binding of coated platelets to recombinant human coagulation factor VIIa.

Knudsen, Tom; Kjalke, Marianne; Tranholm, Mikael; Nichols, Timothy C; Jensen, Asger L; Kristensen, Annemarie T

Knudsen, Tom; Kjalke, Marianne; Tranholm, Mikael; Nichols, Timothy C; Jensen, Asger L; Kristensen, Annemarie T.

Affiliation

Knudsen T; Department of Small Animal Clinical Sciences, Faculty of Life Sciences, University of Copenhagen, 1870 Frederiksberg C, Denmark. tmkn@novonordisk.com

Am J Vet Res ; 72(8): 1007-14, 2011 Aug.

Article in En | MEDLINE | ID: mdl-21801056

Subject(s)

Blood Platelets/metabolism; Factor VIIa/metabolism; Flow Cytometry/veterinary; Platelet Activation; Animals; Antibodies/analysis; Antibodies/metabolism; Blood Platelets/cytology; Crotalid Venoms/metabolism; Disease Models, Animal; Dog Diseases/metabolism; Dog Diseases/physiopathology; Dogs; Fibrinogen/analysis; Fibrinogen/metabolism; Flow Cytometry/methods; Hemophilia A/metabolism; Hemophilia A/physiopathology; Hemophilia A/veterinary; Hemophilia B/metabolism; Hemophilia B/physiopathology; Hemophilia B/veterinary; Humans; Lectins, C-Type/metabolism; P-Selectin/analysis; P-Selectin/metabolism; Protein Binding; Recombinant Proteins/metabolism; Thrombin/metabolism; von Willebrand Diseases/metabolism; von Willebrand Diseases/physiopathology; von Willebrand Diseases/veterinary

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Blood Platelets / Factor VIIa / Platelet Activation / Flow Cytometry Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals / Humans Language: En Journal: Am J Vet Res Year: 2011 Document type: Article Affiliation country: Denmark

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