Up-regulation of spinal glutamate transporters contributes to anti-hypersensitive effects of valproate in rats after peripheral nerve injury.

Hobo, Shotaro; Eisenach, James C; Hayashida, Ken-ichiro

Hobo, Shotaro; Eisenach, James C; Hayashida, Ken-ichiro.

Affiliation

Hobo S; Department of Anesthesiology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.

Neurosci Lett ; 502(1): 52-5, 2011 Sep 08.

Article in En | MEDLINE | ID: mdl-21802494

Subject(s)

Excitatory Amino Acid Transporter 1/biosynthesis; Excitatory Amino Acid Transporter 2/biosynthesis; Hyperalgesia/metabolism; Peripheral Nerve Injuries/metabolism; Valproic Acid/pharmacology; Analgesics/administration & dosage; Analgesics/antagonists & inhibitors; Analgesics/pharmacology; Analgesics/therapeutic use; Animals; Disease Models, Animal; Drug Therapy, Combination; Excitatory Amino Acid Transporter 2/antagonists & inhibitors; Hyperalgesia/drug therapy; Kainic Acid/analogs & derivatives; Kainic Acid/pharmacology; Pain Threshold/drug effects; Peripheral Nerve Injuries/drug therapy; Rats; Rats, Sprague-Dawley; Riluzole/administration & dosage; Riluzole/pharmacology; Riluzole/therapeutic use; Spinal Cord/drug effects; Spinal Cord/metabolism; Up-Regulation; Valproic Acid/administration & dosage; Valproic Acid/antagonists & inhibitors; Valproic Acid/therapeutic use

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Valproic Acid / Excitatory Amino Acid Transporter 1 / Excitatory Amino Acid Transporter 2 / Peripheral Nerve Injuries / Hyperalgesia Limits: Animals Language: En Journal: Neurosci Lett Year: 2011 Document type: Article Affiliation country: United States Country of publication: Ireland

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