Three kidneys, two diseases, one antibody?
Nephrol Dial Transplant
; 26(11): 3811-3, 2011 Nov.
Article
in En
| MEDLINE
| ID: mdl-21813829
ABSTRACT
Anti-factor H antibody has been recently described as responsible for thrombotic microangiopathies (TMA) as well as membranoproliferative glomerulonephritis (MPGN). We report here, for the first time, the case of a woman with an anti-factor H antibody, who developed MPGN on native kidney, rapid recurrence on first graft, and TMA on second graft despite immunosuppressive therapy and plasma exchanges. This case supports the hypothesis that MPGN and TMA are closely linked by common pathogenic mechanisms and the need for complete exploration of complement pathway including factor H activity and autoantibody in front of any MPGN.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Purpura, Thrombotic Thrombocytopenic
/
Autoantibodies
/
Glomerulonephritis, Membranoproliferative
/
Kidney Transplantation
/
Complement Factor H
/
Hemolytic-Uremic Syndrome
/
Kidney Failure, Chronic
Type of study:
Etiology_studies
/
Prognostic_studies
Limits:
Adult
/
Female
/
Humans
Language:
En
Journal:
Nephrol Dial Transplant
Journal subject:
NEFROLOGIA
/
TRANSPLANTE
Year:
2011
Document type:
Article
Affiliation country:
France