Mutant telomerase RNAs induce DNA damage and apoptosis via the TRF2-ATM pathway in telomerase-overexpressing primary fibroblasts.

Mahalingam, Dashayini; Tay, Ling L; Tan, Wei H; Chai, Juin H; Wang, Xueying

Mahalingam, Dashayini; Tay, Ling L; Tan, Wei H; Chai, Juin H; Wang, Xueying.

Affiliation

Mahalingam D; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

FEBS J ; 278(19): 3724-38, 2011 Oct.

Article in En | MEDLINE | ID: mdl-21824286

Subject(s)

Apoptosis/physiology; Cell Cycle Proteins/metabolism; DNA Damage; DNA-Binding Proteins/metabolism; Protein Serine-Threonine Kinases/metabolism; RNA/genetics; RNA/metabolism; Telomerase/metabolism; Telomeric Repeat Binding Protein 2/metabolism; Tumor Suppressor Proteins/metabolism; Animals; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins/genetics; Cell Proliferation; Cells, Cultured; DNA-Binding Proteins/genetics; Fibroblasts/cytology; Fibroblasts/physiology; Humans; Intracellular Signaling Peptides and Proteins/metabolism; Microarray Analysis; Protein Serine-Threonine Kinases/genetics; Signal Transduction/physiology; Telomerase/genetics; Telomere/metabolism; Telomeric Repeat Binding Protein 2/genetics; Tumor Suppressor Protein p53/genetics; Tumor Suppressor Protein p53/metabolism; Tumor Suppressor Proteins/genetics; GADD45 Proteins

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA Damage / RNA / Protein Serine-Threonine Kinases / Apoptosis / Cell Cycle Proteins / Telomerase / Tumor Suppressor Proteins / Telomeric Repeat Binding Protein 2 / DNA-Binding Proteins Limits: Animals / Humans Language: En Journal: FEBS J Journal subject: BIOQUIMICA Year: 2011 Document type: Article Affiliation country: Singapore Country of publication: United kingdom

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