Passive immunization with anti-Tau antibodies in two transgenic models: reduction of Tau pathology and delay of disease progression.

Chai, Xiyun; Wu, Su; Murray, Tracey K; Kinley, Robert; Cella, Claire V; Sims, Helen; Buckner, Nicola; Hanmer, Jenna; Davies, Peter; O'Neill, Michael J; Hutton, Michael L; Citron, Martin

Chai, Xiyun; Wu, Su; Murray, Tracey K; Kinley, Robert; Cella, Claire V; Sims, Helen; Buckner, Nicola; Hanmer, Jenna; Davies, Peter; O'Neill, Michael J; Hutton, Michael L; Citron, Martin.

Affiliation

Chai X; Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, USA.

J Biol Chem ; 286(39): 34457-67, 2011 Sep 30.

Article in En | MEDLINE | ID: mdl-21841002

Subject(s)

Alzheimer Disease/therapy; Antibodies/immunology; Antibodies/pharmacology; Immunization, Passive/methods; tau Proteins/immunology; Alzheimer Disease/genetics; Alzheimer Disease/immunology; Alzheimer Disease/pathology; Amino Acid Substitution/immunology; Animals; Disease Models, Animal; Humans; Mice; Mice, Transgenic; Motor Activity/drug effects; Motor Activity/genetics; Motor Activity/immunology; Mutation, Missense/immunology; tau Proteins/genetics

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Immunization, Passive / Tau Proteins / Alzheimer Disease / Antibodies Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2011 Document type: Article Affiliation country: United States Country of publication: United States

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google