Presenilin 1 regulates homeostatic synaptic scaling through Akt signaling.
Nat Neurosci
; 14(9): 1112-4, 2011 Aug 14.
Article
in En
| MEDLINE
| ID: mdl-21841774
ABSTRACT
Neurons adapt to long-lasting changes in network activity, both in vivo and in vitro, by adjusting their synaptic strengths to stabilize firing rates. We found that homeostatic scaling of excitatory synapses was impaired in hippocampal neurons derived from mice lacking presenilin 1 (Psen1(-/-) mice) or expressing a familial Alzheimer's disease-linked Psen1 mutation (Psen1(M146V)). These findings suggest that deficits in synaptic homeostasis may contribute to brain dysfunction in Alzheimer's disease.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Synapses
/
Signal Transduction
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Oncogene Protein v-akt
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Presenilin-1
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Homeostasis
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Neurons
Limits:
Animals
Language:
En
Journal:
Nat Neurosci
Journal subject:
NEUROLOGIA
Year:
2011
Document type:
Article
Affiliation country:
United States