Pyrrolidin-3-yl-N-methylbenzamides as potent histamine 3 receptor antagonists.
Bioorg Med Chem Lett
; 21(19): 5957-60, 2011 Oct 01.
Article
in En
| MEDLINE
| ID: mdl-21843941
ABSTRACT
On the basis of the previously reported benzimidazole 1,3'-bipyrrolidine benzamides (1), a series of related pyrrolidin-3-yl-N-methylbenzamides were synthesized and evaluated as H(3) receptor antagonists. In particular, compound 32 exhibits potent H(3) receptor binding affinity, improved pharmaceutical properties and a favorable in vivo profile.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pyrrolidines
/
Benzamides
/
Drug Design
/
Histamine H3 Antagonists
Limits:
Animals
/
Humans
Language:
En
Journal:
Bioorg Med Chem Lett
Journal subject:
BIOQUIMICA
/
QUIMICA
Year:
2011
Document type:
Article
Affiliation country:
United States