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Pyrrolidin-3-yl-N-methylbenzamides as potent histamine 3 receptor antagonists.
Zhou, Dahui; Gross, Jonathan L; Sze, Jean Y; Adedoyin, Adedayo B; Bowlby, Mark; Di, Li; Platt, Brian J; Zhang, Guoming; Brandon, Nicholas; Comery, Thomas A; Robichaud, Albert J.
Affiliation
  • Zhou D; Pfizer Global Research and Development, 445 Eastern Point Road, Groton, CT 06340, United States. dahui.zhou@pfizer.com
Bioorg Med Chem Lett ; 21(19): 5957-60, 2011 Oct 01.
Article in En | MEDLINE | ID: mdl-21843941
ABSTRACT
On the basis of the previously reported benzimidazole 1,3'-bipyrrolidine benzamides (1), a series of related pyrrolidin-3-yl-N-methylbenzamides were synthesized and evaluated as H(3) receptor antagonists. In particular, compound 32 exhibits potent H(3) receptor binding affinity, improved pharmaceutical properties and a favorable in vivo profile.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrrolidines / Benzamides / Drug Design / Histamine H3 Antagonists Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2011 Document type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrrolidines / Benzamides / Drug Design / Histamine H3 Antagonists Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2011 Document type: Article Affiliation country: United States