Cutting edge: Crohn's disease-associated Nod2 mutation limits production of proinflammatory cytokines to protect the host from Enterococcus faecalis-induced lethality.

Kim, Yun-Gi; Shaw, Michael H; Warner, Neil; Park, Jong-Hwan; Chen, Felicia; Ogura, Yasunori; Núñez, Gabriel

Kim, Yun-Gi; Shaw, Michael H; Warner, Neil; Park, Jong-Hwan; Chen, Felicia; Ogura, Yasunori; Núñez, Gabriel.

Affiliation

Kim YG; Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

J Immunol ; 187(6): 2849-52, 2011 Sep 15.

Article in En | MEDLINE | ID: mdl-21849681

Subject(s)

Crohn Disease/genetics; Enterococcus faecalis/immunology; Gram-Positive Bacterial Infections/genetics; Macrophages/immunology; Mutation; Nod2 Signaling Adaptor Protein/genetics; Animals; Crohn Disease/immunology; Cytokines/biosynthesis; Cytokines/immunology; Gene Knock-In Techniques; Gram-Positive Bacterial Infections/immunology; Immunoblotting; Inflammation/genetics; Inflammation/immunology; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Mutant Strains; Nod2 Signaling Adaptor Protein/immunology; Reverse Transcriptase Polymerase Chain Reaction

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Crohn Disease / Gram-Positive Bacterial Infections / Enterococcus faecalis / Nod2 Signaling Adaptor Protein / Macrophages / Mutation Type of study: Risk_factors_studies Limits: Animals Language: En Journal: J Immunol Year: 2011 Document type: Article Affiliation country: United States Country of publication: United States

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