Anandamide inhibits Theiler's virus induced VCAM-1 in brain endothelial cells and reduces leukocyte transmigration in a model of blood brain barrier by activation of CB(1) receptors.

Mestre, Leyre; Iñigo, Paula M; Mecha, Miriam; Correa, Fernando G; Hernangómez-Herrero, Miriam; Loría, Frida; Docagne, Fabian; Borrell, José; Guaza, Carmen

Mestre, Leyre; Iñigo, Paula M; Mecha, Miriam; Correa, Fernando G; Hernangómez-Herrero, Miriam; Loría, Frida; Docagne, Fabian; Borrell, José; Guaza, Carmen.

Affiliation

Mestre L; Neuroimmunology Group, Functional and Systems Neurobiology Department, Cajal Institute, CSIC, 28002 Madrid, Spain.

J Neuroinflammation ; 8: 102, 2011 Aug 18.

Article in En | MEDLINE | ID: mdl-21851608

Subject(s)

Arachidonic Acids/pharmacology; Blood-Brain Barrier/metabolism; Endothelial Cells/drug effects; Leukocytes/physiology; Polyunsaturated Alkamides/pharmacology; Receptor, Cannabinoid, CB1/metabolism; Theilovirus/metabolism; Transendothelial and Transepithelial Migration/drug effects; Vascular Cell Adhesion Molecule-1/metabolism; Animals; Brain/cytology; Brain/drug effects; Brain/metabolism; Cannabinoid Receptor Modulators/pharmacology; Cell Adhesion/drug effects; Endocannabinoids; Endothelial Cells/cytology; Endothelial Cells/metabolism; Female; Humans; Leukocytes/cytology; Leukocytes/drug effects; Mice; Mice, Knockout; Microglia/metabolism; Theilovirus/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Blood-Brain Barrier / Arachidonic Acids / Theilovirus / Vascular Cell Adhesion Molecule-1 / Endothelial Cells / Receptor, Cannabinoid, CB1 / Polyunsaturated Alkamides / Transendothelial and Transepithelial Migration / Leukocytes Limits: Animals / Female / Humans Language: En Journal: J Neuroinflammation Journal subject: NEUROLOGIA Year: 2011 Document type: Article Affiliation country: Spain

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