Reactive oxygen species mediate arsenic induced cell transformation and tumorigenesis through Wnt/ß-catenin pathway in human colorectal adenocarcinoma DLD1 cells.

Zhang, Zhuo; Wang, Xin; Cheng, Senping; Sun, Lijuan; Son, Young-Ok; Yao, Hua; Li, Wenqi; Budhraja, Amit; Li, Li; Shelton, Brent J; Tucker, Thomas; Arnold, Susanne M; Shi, Xianglin

Zhang, Zhuo; Wang, Xin; Cheng, Senping; Sun, Lijuan; Son, Young-Ok; Yao, Hua; Li, Wenqi; Budhraja, Amit; Li, Li; Shelton, Brent J; Tucker, Thomas; Arnold, Susanne M; Shi, Xianglin.

Affiliation

Zhang Z; Department of Preventive Medicine and Environmental Health, University of Kentucky, 121 Washington Avenue, Lexington, KY 40536, USA.

Toxicol Appl Pharmacol ; 256(2): 114-21, 2011 Oct 15.

Article in En | MEDLINE | ID: mdl-21854796

Subject(s)

Adenocarcinoma/physiopathology; Arsenicals/pharmacology; Catenins/physiology; Cell Transformation, Neoplastic/drug effects; Colorectal Neoplasms/physiopathology; Reactive Oxygen Species/metabolism; Signal Transduction/drug effects; Wnt Proteins/physiology; Adenocarcinoma/metabolism; Animals; Blotting, Western; Carcinogenicity Tests; Catenins/drug effects; Cell Line, Tumor; Cell Transformation, Neoplastic/metabolism; Colorectal Neoplasms/metabolism; Electron Spin Resonance Spectroscopy; Enzyme Activation/drug effects; Humans; Male; Mice; Mice, Nude; NADPH Oxidases/metabolism; Signal Transduction/physiology; Wnt Proteins/drug effects; beta Catenin/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arsenicals / Colorectal Neoplasms / Adenocarcinoma / Signal Transduction / Cell Transformation, Neoplastic / Reactive Oxygen Species / Wnt Proteins / Catenins Limits: Animals / Humans / Male Language: En Journal: Toxicol Appl Pharmacol Year: 2011 Document type: Article Affiliation country: United States Country of publication: United States

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