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Targeting DC-SIGN via its neck region leads to prolonged antigen residence in early endosomes, delayed lysosomal degradation, and cross-presentation.
Tacken, Paul J; Ginter, Wiebke; Berod, Luciana; Cruz, Luis J; Joosten, Ben; Sparwasser, Tim; Figdor, Carl G; Cambi, Alessandra.
Affiliation
  • Tacken PJ; Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
Blood ; 118(15): 4111-9, 2011 Oct 13.
Article in En | MEDLINE | ID: mdl-21860028
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Endosomes / Dendritic Cells / Cell Adhesion Molecules / Antigen Presentation / Receptors, Cell Surface / CD8-Positive T-Lymphocytes / Lectins, C-Type / Cross-Priming / Lysosomes Limits: Animals / Humans Language: En Journal: Blood Year: 2011 Document type: Article Affiliation country: Netherlands
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Endosomes / Dendritic Cells / Cell Adhesion Molecules / Antigen Presentation / Receptors, Cell Surface / CD8-Positive T-Lymphocytes / Lectins, C-Type / Cross-Priming / Lysosomes Limits: Animals / Humans Language: En Journal: Blood Year: 2011 Document type: Article Affiliation country: Netherlands