Inhibition of activated pericentromeric SINE/Alu repeat transcription in senescent human adult stem cells reinstates self-renewal.

Wang, Jianrong; Geesman, Glenn J; Hostikka, Sirkka Liisa; Atallah, Michelle; Blackwell, Benjamin; Lee, Elbert; Cook, Peter J; Pasaniuc, Bogdan; Shariat, Goli; Halperin, Eran; Dobke, Marek; Rosenfeld, Michael G; Jordan, I King; Lunyak, Victoria V

Wang, Jianrong; Geesman, Glenn J; Hostikka, Sirkka Liisa; Atallah, Michelle; Blackwell, Benjamin; Lee, Elbert; Cook, Peter J; Pasaniuc, Bogdan; Shariat, Goli; Halperin, Eran; Dobke, Marek; Rosenfeld, Michael G; Jordan, I King; Lunyak, Victoria V.

Affiliation

Wang J; School of Biology, Georgia Institute of Technology, Atlanta, GA, USA.

Cell Cycle ; 10(17): 3016-30, 2011 Sep 01.

Article in En | MEDLINE | ID: mdl-21862875

Subject(s)

Adult Stem Cells/cytology; Alu Elements; Cellular Senescence; DNA Damage; Transcriptional Activation; Adenosine Triphosphatases/metabolism; Adipose Tissue/cytology; Adipose Tissue/metabolism; Adult Stem Cells/metabolism; Cell Cycle Proteins/metabolism; Cell Nucleus/genetics; Cell Nucleus/metabolism; Cell Proliferation; Centromere/genetics; Centromere/metabolism; Chromatin/genetics; Chromatin/metabolism; Chromosomal Proteins, Non-Histone/metabolism; Chromosomes, Human/metabolism; DNA Repair; DNA Replication; DNA-Binding Proteins/metabolism; Fluorescent Antibody Technique; Histones/metabolism; Humans; Lentivirus/genetics; Lentivirus/metabolism; Multiprotein Complexes/metabolism; Transfection; Cohesins

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA Damage / Transcriptional Activation / Cellular Senescence / Alu Elements / Adult Stem Cells Limits: Humans Language: En Journal: Cell Cycle Year: 2011 Document type: Article Affiliation country: United States Country of publication: United States

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