Specific and prolonged proteasome inhibition dictates apoptosis induction by marizomib and its analogs.

Miller, Claudia P; Manton, Christa A; Hale, Randal; Debose, LaKeisha; Macherla, Venkat R; Potts, Barbara C; Palladino, Michael A; Chandra, Joya

Miller, Claudia P; Manton, Christa A; Hale, Randal; Debose, LaKeisha; Macherla, Venkat R; Potts, Barbara C; Palladino, Michael A; Chandra, Joya.

Affiliation

Miller CP; Department of Pediatrics Research, Children's Cancer Hospital at M.D. Anderson, University of Texas M.D. Anderson Cancer Center, Houston, United States.

Chem Biol Interact ; 194(1): 58-68, 2011 Oct 15.

Article in En | MEDLINE | ID: mdl-21864512

Subject(s)

Apoptosis/drug effects; Lactones/pharmacology; Protease Inhibitors/pharmacology; Pyrroles/pharmacology; Caspase 8/metabolism; Humans; Lactones/chemistry; Leukemia/drug therapy; Leukemia/metabolism; Leukemia/pathology; Oxidative Stress/drug effects; Protease Inhibitors/chemistry; Pyrroles/chemistry; Reactive Oxygen Species/metabolism; Tumor Cells, Cultured

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protease Inhibitors / Pyrroles / Apoptosis / Lactones Limits: Humans Language: En Journal: Chem Biol Interact Year: 2011 Document type: Article Affiliation country: United States

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