Exploration of overloaded cation exchange chromatography for monoclonal antibody purification.

Liu, Hui F; McCooey, Beth; Duarte, Tiago; Myers, Deanna E; Hudson, Terry; Amanullah, Ashraf; van Reis, Robert; Kelley, Brian D

Liu, Hui F; McCooey, Beth; Duarte, Tiago; Myers, Deanna E; Hudson, Terry; Amanullah, Ashraf; van Reis, Robert; Kelley, Brian D.

Affiliation

Liu HF; Oceanside Process Research & Development, Genentech, Inc, Oceanside, CA, USA. huifliu1@live.com

J Chromatogr A ; 1218(39): 6943-52, 2011 Sep 28.

Article in En | MEDLINE | ID: mdl-21871630

Subject(s)

Antibodies, Monoclonal/isolation & purification; Chromatography, Ion Exchange/methods; Staphylococcal Protein A/chemistry; Animals; Antibodies, Monoclonal/chemistry; Antibodies, Monoclonal/metabolism; CHO Cells; Cation Exchange Resins; Chromatography, Affinity/methods; Cricetinae; Cricetulus; DNA/chemistry; DNA/isolation & purification; Humans; Immunoglobulin G/chemistry; Immunoglobulin G/isolation & purification; Immunoglobulin G/metabolism; Membranes, Artificial; Molecular Weight; Protein Binding; Proteins/chemistry; Proteins/isolation & purification

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Staphylococcal Protein A / Chromatography, Ion Exchange / Antibodies, Monoclonal Limits: Animals / Humans Language: En Journal: J Chromatogr A Year: 2011 Document type: Article Affiliation country: United States Country of publication: Netherlands

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