Glycosphingolipid synthesis employing a combination of recombinant glycosyltransferases and an endoglycoceramidase glycosynthase.
Chem Commun (Camb)
; 47(38): 10806-8, 2011 Oct 14.
Article
in En
| MEDLINE
| ID: mdl-21879043
ABSTRACT
Glycosynthase mutants of Rhodococcus sp. endo-glycoceramidase II efficiently synthesize complex glycosphingolipids. Glycosyl fluoride donors may be assembled via sequential glycosyltransferase-catalysed glycosylation of lactosyl fluoride. Alternatively, lactosyl fluoride may be coupled to sphingosine prior to subsequent glycosylation steps.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Glycosphingolipids
/
Glycosyltransferases
/
Glycoside Hydrolases
Language:
En
Journal:
Chem Commun (Camb)
Journal subject:
QUIMICA
Year:
2011
Document type:
Article