Toward functional Ni-SOD biomimetics: achieving a structural/electronic correlation with redox dynamics.
Inorg Chem
; 50(19): 9216-8, 2011 Oct 03.
Article
in En
| MEDLINE
| ID: mdl-21888395
ABSTRACT
We have prepared and characterized a Ni complex with an N(3)S(2) ligand set (1) that represents the first isolable synthetic model of the reduced form of the Ni-SOD (SOD = superoxide dismutase) active site featuring all relevant donor functionality in the proper spatial distribution. As revealed by X-ray crystallography, the axial py-N donor of 1 does not bind Ni(II) in the solid state or in solution like SOD. Oxidation of 1 provides a disulfide-linked dinuclear species, [{Ni(N(3)S(2))}(2)] (2), which we have isolated and characterized. Moreover, the 1 â 2 conversion is reversible, much like redox cycling in the enzyme.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Organometallic Compounds
/
Superoxide Dismutase
/
Biomimetic Materials
/
Nickel
Language:
En
Journal:
Inorg Chem
Year:
2011
Document type:
Article
Affiliation country:
United States