Evolution of hepatitis B virus during long-term therapy in patients with chronic hepatitis B.
Ann Hepatol
; 10(4): 434-40, 2011.
Article
in En
| MEDLINE
| ID: mdl-21911882
ABSTRACT
BACKGROUND:
Long-term lamivudine (LAM), adefovir (ADV) and entecavir (ETV) treatment induce the emergence of drug-resistant hepatitis B virus (HBV) in patients with chronic hepatitis B infection.AIM:
To evaluate the LAM, ADV and ETV resistance mutations detected in our patient group. MATERIALS ANDMETHODS:
Twenty patients who had received at least two years of treatment with nucleoside/tide analogues were enrolled in this study. Patients with detectable HBV DNA were analyzed in order to detect resistance mutations and in this group of patients treatment was change.RESULTS:
Three patients developed LAM resistance mutations (2 presented rtM204I and one rtL180M+rtM204V/I) and one patient showed rtN236T ADV resistance mutation. During ADV and LAM treatment, one patient developed ADV plus LAM resistance mutations (rtI163V+rtL180M+rtA181V+rtN236T), in this case, HBV strains harbouring polymerase mutations did not develop LAM associated rtM204V/I primary mutation. In addition, ETV resistance mutations (rtL180M+rtT184A+rtS202G+rtM204V) were detected in one patient.CONCLUSIONS:
These findings suggest that monotherapy resulted in a limited virological response and combination strategies including potent antiviral agents should be recommended for patients with resistant mutations.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Antiviral Agents
/
Adenine
/
Hepatitis B virus
/
Lamivudine
/
Hepatitis B, Chronic
/
Drug Resistance, Viral
/
Organophosphonates
/
Guanine
Type of study:
Diagnostic_studies
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Europa
Language:
En
Journal:
Ann Hepatol
Journal subject:
GASTROENTEROLOGIA
Year:
2011
Document type:
Article
Affiliation country:
Spain