[Methylation of insulin-like growth factor binding protein 3 gene in neonates with intrauterine growth restriction].
Zhongguo Dang Dai Er Ke Za Zhi
; 13(9): 700-3, 2011 Sep.
Article
in Zh
| MEDLINE
| ID: mdl-21924014
ABSTRACT
OBJECTIVE:
To study the role of promoter methylation of insulin-like growth factor binding protein 3 (IGFBP3) in intrauterine growth restriction (IUGR).METHODS:
Fifty neonates with IUGR and 30 healthy neonates were enrolled. The promoter methylation status of IGFBP3 in peripheral blood was evaluated by methylation-specific PCR (MSP) and high resolution melting (HRM) techniques.RESULTS:
The complete methylation rate, partial methylation rate and non-methylation rate of IGFBP3 promoter in the IUGR group was 4% (2/50), 40% (20/50) and 56% (28/50), respectively. The partial methylation rate and non-methylation rate of IGFBP3 promoter in the control group were 13% (4/30) and 87% (26/30), respectively. There were significant differences in the promoter methylation rate of IGFBP3 between the two groups (P<0.01).CONCLUSIONS:
The promoter methylation of IGFBP3 gene is associated with the pathogenesis of IUGR.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Insulin-Like Growth Factor Binding Protein 3
/
DNA Methylation
/
Fetal Growth Retardation
Limits:
Female
/
Humans
/
Male
/
Newborn
Language:
Zh
Journal:
Zhongguo Dang Dai Er Ke Za Zhi
Year:
2011
Document type:
Article
Affiliation country:
China