PTEN deficiency in mast cells causes a mastocytosis-like proliferative disease that heightens allergic responses and vascular permeability.

Furumoto, Yasuko; Charles, Nicolas; Olivera, Ana; Leung, Wai Hang; Dillahunt, Sandra; Sargent, Jennifer L; Tinsley, Kevin; Odom, Sandra; Scott, Eric; Wilson, Todd M; Ghoreschi, Kamran; Kneilling, Manfred; Chen, Mei; Lee, David M; Bolland, Silvia; Rivera, Juan

Furumoto, Yasuko; Charles, Nicolas; Olivera, Ana; Leung, Wai Hang; Dillahunt, Sandra; Sargent, Jennifer L; Tinsley, Kevin; Odom, Sandra; Scott, Eric; Wilson, Todd M; Ghoreschi, Kamran; Kneilling, Manfred; Chen, Mei; Lee, David M; Bolland, Silvia; Rivera, Juan.

Affiliation

Furumoto Y; Laboratory of Molecular Immunogenetics, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD 20892, USA.

Blood ; 118(20): 5466-75, 2011 Nov 17.

Article in En | MEDLINE | ID: mdl-21926349

Subject(s)

Capillary Permeability/immunology; Hypersensitivity/pathology; Mast Cells/pathology; Mast Cells/physiology; Mastocytosis/pathology; PTEN Phosphohydrolase/genetics; Adoptive Transfer; Animals; Bone Marrow Cells/cytology; Bone Marrow Cells/physiology; Cell Degranulation/immunology; Cell Division/immunology; Cell Survival/immunology; Cells, Cultured; Disease Models, Animal; Hypersensitivity/immunology; Hypersensitivity/physiopathology; Mastocytosis/immunology; Mastocytosis/physiopathology; Mice; Mice, Mutant Strains; PTEN Phosphohydrolase/metabolism; Phosphatidylinositol 3-Kinases/metabolism; Signal Transduction/immunology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Mastocytosis / Capillary Permeability / PTEN Phosphohydrolase / Hypersensitivity / Mast Cells Type of study: Etiology_studies / Prognostic_studies Limits: Animals Language: En Journal: Blood Year: 2011 Document type: Article Affiliation country: United States

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