A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable.

Tian, Hua; Biehs, Brian; Warming, Søren; Leong, Kevin G; Rangell, Linda; Klein, Ophir D; de Sauvage, Frederic J

Tian, Hua; Biehs, Brian; Warming, Søren; Leong, Kevin G; Rangell, Linda; Klein, Ophir D; de Sauvage, Frederic J.

Affiliation

Tian H; Department of Molecular Biology, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA.

Nature ; 478(7368): 255-9, 2011 Sep 18.

Article in En | MEDLINE | ID: mdl-21927002

Subject(s)

Intestine, Small/cytology; Nuclear Proteins/metabolism; Proto-Oncogene Proteins/metabolism; Receptors, G-Protein-Coupled/metabolism; Repressor Proteins/metabolism; Stem Cells/cytology; Animals; Cell Lineage; Epithelial Cells/cytology; Epithelial Cells/metabolism; Female; Heparin-binding EGF-like Growth Factor; Homeostasis; Humans; Intercellular Signaling Peptides and Proteins/genetics; Intercellular Signaling Peptides and Proteins/metabolism; Intestine, Small/metabolism; Male; Mice; Mice, Inbred C57BL; Polycomb Repressive Complex 1; Receptors, G-Protein-Coupled/deficiency; Receptors, G-Protein-Coupled/genetics; Regeneration; Stem Cells/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Repressor Proteins / Stem Cells / Nuclear Proteins / Proto-Oncogene Proteins / Receptors, G-Protein-Coupled / Intestine, Small Type of study: Prognostic_studies Limits: Animals / Female / Humans / Male Language: En Journal: Nature Year: 2011 Document type: Article Affiliation country: United States Country of publication: United kingdom

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