Ehrlichia chaffeensis induces monocyte inflammatory responses through MyD88, ERK, and NF-&#954;B but not through TRIF, interleukin-1 receptor 1 (IL-1R1)/IL-18R1, or toll-like receptors.

Miura, Koshiro; Matsuo, Junji; Rahman, M Akhlakur; Kumagai, Yumi; Li, Xin; Rikihisa, Yasuko

Ehrlichia chaffeensis induces monocyte inflammatory responses through MyD88, ERK, and NF-κB but not through TRIF, interleukin-1 receptor 1 (IL-1R1)/IL-18R1, or toll-like receptors.

Miura, Koshiro; Matsuo, Junji; Rahman, M Akhlakur; Kumagai, Yumi; Li, Xin; Rikihisa, Yasuko.

Affiliation

Miura K; Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA.

Infect Immun ; 79(12): 4947-56, 2011 Dec.

Article in En | MEDLINE | ID: mdl-21930764

Subject(s)

Cytokines/metabolism; Ehrlichia chaffeensis; Mitogen-Activated Protein Kinase 1/metabolism; Monocytes/metabolism; Myeloid Differentiation Factor 88/metabolism; NF-kappa B/metabolism; Adaptor Proteins, Vesicular Transport/genetics; Adaptor Proteins, Vesicular Transport/metabolism; Animals; Cytokines/antagonists & inhibitors; Cytokines/genetics; Gene Expression Regulation/physiology; HEK293 Cells; Humans; Inflammation/genetics; Inflammation/metabolism; Macrophages/metabolism; Macrophages/microbiology; Mice; Mice, Knockout; Mitogen-Activated Protein Kinase 1/genetics; Monocytes/microbiology; Myeloid Differentiation Factor 88/genetics; NF-kappa B/genetics; Promoter Regions, Genetic; Receptors, Interleukin-1 Type I/genetics; Receptors, Interleukin-1 Type I/metabolism; Toll-Like Receptors/genetics; Toll-Like Receptors/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Monocytes / Cytokines / NF-kappa B / Ehrlichia chaffeensis / Mitogen-Activated Protein Kinase 1 / Myeloid Differentiation Factor 88 Limits: Animals / Humans Language: En Journal: Infect Immun Year: 2011 Document type: Article Affiliation country: United States

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