Inhibitory effect of 10-hydroxy-trans-2-decenoic acid on LPS-induced IL-6 production via reducing I&#954;B-Î¶ expression.

Sugiyama, Tsuyoshi; Takahashi, Keita; Tokoro, Shunji; Gotou, Takaki; Neri, Paola; Mori, Hiroshi

Inhibitory effect of 10-hydroxy-trans-2-decenoic acid on LPS-induced IL-6 production via reducing IκB-Î¶ expression.

Sugiyama, Tsuyoshi; Takahashi, Keita; Tokoro, Shunji; Gotou, Takaki; Neri, Paola; Mori, Hiroshi.

Affiliation

Sugiyama T; Department of Biopharmaceutical Sciences, Laboratory of Microbiology, Gifu Pharmaceutical University, Gifu, Japan. sugiyama@gifu-pu.ac.jp

Innate Immun ; 18(3): 429-37, 2012 Jun.

Article in En | MEDLINE | ID: mdl-21948282

Subject(s)

Anti-Inflammatory Agents/pharmacology; Fatty Acids, Monounsaturated/pharmacology; I-kappa B Kinase/metabolism; Interleukin-6/metabolism; Macrophages/immunology; Acute-Phase Proteins/genetics; Acute-Phase Proteins/metabolism; Animals; Anti-Inflammatory Agents/chemistry; Cell Line; Down-Regulation; Fatty Acids/chemistry; Fatty Acids, Monounsaturated/chemistry; Granulocyte Colony-Stimulating Factor/genetics; Granulocyte Colony-Stimulating Factor/metabolism; I-kappa B Kinase/genetics; Interleukin-6/genetics; Lipocalin-2; Lipocalins/genetics; Lipocalins/metabolism; Lipopolysaccharides/immunology; Lipopolysaccharides/metabolism; Macrophage Activation/drug effects; Macrophages/drug effects; Mice; Oncogene Proteins/genetics; Oncogene Proteins/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Fatty Acids, Monounsaturated / Interleukin-6 / I-kappa B Kinase / Macrophages / Anti-Inflammatory Agents Limits: Animals Language: En Journal: Innate Immun Journal subject: ALERGIA E IMUNOLOGIA / BACTERIOLOGIA Year: 2012 Document type: Article Affiliation country: Japan

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