Tumor necrosis factor-&#945; and Muc2 mucin play major roles in disease onset and progression in dextran sodium sulphate-induced colitis.

Dharmani, Poonam; Leung, Pearl; Chadee, Kris

Tumor necrosis factor-α and Muc2 mucin play major roles in disease onset and progression in dextran sodium sulphate-induced colitis.

Dharmani, Poonam; Leung, Pearl; Chadee, Kris.

Affiliation

Dharmani P; Department of Microbiology, Immunology and Infectious Diseases, Gastrointestinal Research Group, Health Sciences Centre, University of Calgary, Calgary, Alberta, Canada.

PLoS One ; 6(9): e25058, 2011.

Article in En | MEDLINE | ID: mdl-21949848

Subject(s)

Colitis/metabolism; Colitis/pathology; Dextran Sulfate/toxicity; Mucin-2/metabolism; Tumor Necrosis Factor-alpha/metabolism; Animals; Blotting, Western; Cells, Cultured; Colitis/chemically induced; Disease Progression; Epithelial Cells/metabolism; Goblet Cells/metabolism; Immunoenzyme Techniques; Interleukin-10/metabolism; Male; Mucin-2/genetics; RNA, Messenger/genetics; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Tumor Necrosis Factor-alpha/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Dextran Sulfate / Tumor Necrosis Factor-alpha / Colitis / Mucin-2 Limits: Animals Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2011 Document type: Article Affiliation country: Canada Country of publication: United States

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