Neuroinflammation and endoplasmic reticulum stress are coregulated by crocin to prevent demyelination and neurodegeneration.

Deslauriers, André M; Afkhami-Goli, Amir; Paul, Amber M; Bhat, Rakesh K; Acharjee, Shaona; Ellestad, Kristofor K; Noorbakhsh, Farshid; Michalak, Marek; Power, Christopher

Deslauriers, André M; Afkhami-Goli, Amir; Paul, Amber M; Bhat, Rakesh K; Acharjee, Shaona; Ellestad, Kristofor K; Noorbakhsh, Farshid; Michalak, Marek; Power, Christopher.

Affiliation

Deslauriers AM; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta T6G 2S2, Canada.

J Immunol ; 187(9): 4788-99, 2011 Nov 01.

Article in En | MEDLINE | ID: mdl-21964030

Subject(s)

Carotenoids/therapeutic use; Demyelinating Diseases/prevention & control; Endoplasmic Reticulum/metabolism; Endoplasmic Reticulum/pathology; Inflammation Mediators/therapeutic use; Neurodegenerative Diseases/prevention & control; Animals; Carotenoids/administration & dosage; Cells, Cultured; Demyelinating Diseases/pathology; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental/drug therapy; Encephalomyelitis, Autoimmune, Experimental/pathology; Endoplasmic Reticulum/drug effects; Female; Free Radical Scavengers/therapeutic use; Frontal Lobe/drug effects; Frontal Lobe/metabolism; Frontal Lobe/pathology; Humans; Inflammation Mediators/administration & dosage; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Neurodegenerative Diseases/pathology; Rats; Rats, Sprague-Dawley

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carotenoids / Demyelinating Diseases / Inflammation Mediators / Neurodegenerative Diseases / Endoplasmic Reticulum Type of study: Prognostic_studies Limits: Animals / Female / Humans / Male / Middle aged Language: En Journal: J Immunol Year: 2011 Document type: Article Affiliation country: Canada Country of publication: United States

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