Synthesis and radioligand binding studies of bis-(8-isopropyl-isoquinolinium) derivatives as ligands for apamin-sensitive sites on cloned SK2 and SK3 channels.

Badarau, Eduard; Dilly, Sébastien; Dufour, Fabien; Poncin, Sylvie; Seutin, Vincent; Liégeois, Jean-François

Badarau, Eduard; Dilly, Sébastien; Dufour, Fabien; Poncin, Sylvie; Seutin, Vincent; Liégeois, Jean-François.

Affiliation

Badarau E; Laboratory of Medicinal Chemistry and C.I.R.M., University of Liège, 1 Avenue de l'Hôpital (B36), B-4000 Liège 1, Belgium.

Bioorg Med Chem Lett ; 21(22): 6756-9, 2011 Nov 15.

Article in En | MEDLINE | ID: mdl-21978678

Subject(s)

2-Propanol/chemistry; 2-Propanol/pharmacology; Apamin/metabolism; Isoquinolines/chemistry; Isoquinolines/pharmacology; Small-Conductance Calcium-Activated Potassium Channels/metabolism; 2-Propanol/chemical synthesis; Binding Sites; HEK293 Cells; Humans; Isoquinolines/chemical synthesis; Ligands; Models, Molecular; Protein Binding; Radioligand Assay; Small-Conductance Calcium-Activated Potassium Channels/chemistry; Structure-Activity Relationship

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Apamin / 2-Propanol / Small-Conductance Calcium-Activated Potassium Channels / Isoquinolines Type of study: Diagnostic_studies Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2011 Document type: Article Affiliation country: Belgium Country of publication: United kingdom

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