Antagonism of peripheral hepatic cannabinoid receptor-1 improves liver lipid metabolism in mice: evidence from cultured explants.

Jourdan, Tony; Demizieux, Laurent; Gresti, Joseph; Djaouti, Louiza; Gaba, Lila; Vergès, Bruno; Degrace, Pascal

Jourdan, Tony; Demizieux, Laurent; Gresti, Joseph; Djaouti, Louiza; Gaba, Lila; Vergès, Bruno; Degrace, Pascal.

Affiliation

Jourdan T; UMR 866 INSERM-UB, Team Physiopathology of Dyslipidemia, Faculty of Sciences, Dijon, France.

Hepatology ; 55(3): 790-9, 2012 Mar.

Article in En | MEDLINE | ID: mdl-21987372

Subject(s)

Lipid Metabolism/drug effects; Liver/metabolism; Obesity/metabolism; Piperidines/pharmacology; Pyrazoles/pharmacology; Receptor, Cannabinoid, CB1/antagonists & inhibitors; Receptor, Cannabinoid, CB1/drug effects; AMP-Activated Protein Kinase Kinases; Animals; Carbohydrate Metabolism/drug effects; Cholesterol/metabolism; Disease Models, Animal; Dyslipidemias/etiology; Dyslipidemias/metabolism; Dyslipidemias/prevention & control; Fatty Liver/etiology; Fatty Liver/metabolism; Fatty Liver/prevention & control; Gene Expression Regulation/drug effects; Lipid Metabolism/physiology; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Obesity/complications; Obesity/physiopathology; Oxygen Consumption/drug effects; Protein Kinases/metabolism; RNA, Messenger/metabolism; Receptor, Cannabinoid, CB1/genetics; Rimonabant; Tissue Culture Techniques

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperidines / Pyrazoles / Receptor, Cannabinoid, CB1 / Lipid Metabolism / Liver / Obesity Type of study: Etiology_studies Limits: Animals Language: En Journal: Hepatology Year: 2012 Document type: Article Affiliation country: France Country of publication: United States

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