Aryl-aryl bond formation by the fluoride-free cross-coupling of aryldisiloxanes with aryl bromides.
Chemistry
; 17(47): 13230-9, 2011 Nov 18.
Article
in En
| MEDLINE
| ID: mdl-21990071
ABSTRACT
The prevalence of the biaryl structural motif in biologically interesting and synthetically important molecules has inspired considerable interest in the development of methods for aryl-aryl bond formation. Herein we describe a novel strategy for this process involving the fluoride-free, palladium-catalysed cross-coupling of readily accessible aryldisiloxanes and aryl bromides. Using a statistical-based optimisation process, preparatively useful reaction conditions were formulated to allow the cross-coupling of a wide range of different substrates. This methodology represents an attractive, cost-efficient, flexible and robust alternative to the traditional transition-metal-catalysed routes typically used to generate molecules containing the privileged biaryl scaffold.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Palladium
/
Siloxanes
/
Cross-Linking Reagents
/
Fluorides
/
Hydrocarbons, Brominated
Type of study:
Risk_factors_studies
Language:
En
Journal:
Chemistry
Journal subject:
QUIMICA
Year:
2011
Document type:
Article
Affiliation country:
United kingdom