Enhancement of TGF-ß signaling responses by the E3 ubiquitin ligase Arkadia provides tumor suppression in colorectal cancer.

Sharma, Vikas; Antonacopoulou, Anna G; Tanaka, Shinya; Panoutsopoulos, Alexios A; Bravou, Vasiliki; Kalofonos, Haralabos P; Episkopou, Vasso

Sharma, Vikas; Antonacopoulou, Anna G; Tanaka, Shinya; Panoutsopoulos, Alexios A; Bravou, Vasiliki; Kalofonos, Haralabos P; Episkopou, Vasso.

Affiliation

Sharma V; Department of Experimental Medicine, Imperial College, Hammersmith Hospital Campus, London, United Kingdom.

Cancer Res ; 71(20): 6438-49, 2011 Oct 15.

Article in En | MEDLINE | ID: mdl-21998011

Subject(s)

Adenocarcinoma/metabolism; Colorectal Neoplasms/metabolism; Nuclear Proteins/metabolism; Transforming Growth Factor beta/metabolism; Tumor Suppressor Proteins/metabolism; Ubiquitin-Protein Ligases/metabolism; Amino Acid Sequence; Animals; Azoxymethane/toxicity; Base Sequence; Colon/metabolism; Colorectal Neoplasms/chemically induced; Gene Expression Regulation, Neoplastic; HEK293 Cells; Humans; Intracellular Signaling Peptides and Proteins/metabolism; Mice; Molecular Sequence Data; Mutation; Nuclear Proteins/genetics; Proto-Oncogene Proteins/metabolism; Severity of Illness Index; Signal Transduction; Smad2 Protein/metabolism; Ubiquitin-Protein Ligases/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Nuclear Proteins / Colorectal Neoplasms / Adenocarcinoma / Transforming Growth Factor beta / Tumor Suppressor Proteins / Ubiquitin-Protein Ligases Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Cancer Res Year: 2011 Document type: Article Affiliation country: United kingdom Country of publication: United States

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