Biocompatibility of acellular nerves of different mammalian species for nerve tissue engineering.
Artif Cells Blood Substit Immobil Biotechnol
; 39(6): 366-75, 2011 Dec.
Article
in En
| MEDLINE
| ID: mdl-21999105
ABSTRACT
To explore the biocompatibility of acellular nerves of different mammalian species, for the acellular nerves derived from rats and rabbits, the morphology, immunocompatibility, and cytocompatibility with bone marrow stromal cells (BMSCs) were evaluated. The results indicated that the tridimensional architecture and main proteins of endoneurial tubes in both biomaterials were well retained. The nerve scaffolds did not show immunogenicity or cytotoxicity, but facilitated growth of BMSCs and secretion of neurotrophic factors in vitro. In conclusion, acellular nerves of different species possess favorable biocompatibility, and xenogenic acellular nerves combined with BMSCs have potential to replace allografts for peripheral nerve reconstruction.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Materials Testing
/
Tissue Engineering
/
Tissue Scaffolds
/
Nerve Tissue
/
Nerve Tissue Proteins
Limits:
Animals
Language:
En
Journal:
Artif Cells Blood Substit Immobil Biotechnol
Journal subject:
BIOTECNOLOGIA
/
TRANSPLANTE
Year:
2011
Document type:
Article
Affiliation country:
China