Suppression of IL-8 production from airway cells by tiotropium bromide in vitro.

Suzaki, Isao; Asano, Kazuhito; Shikama, Yusuke; Hamasaki, Taisuke; Kanei, Ayako; Suzaki, Harumi

Suzaki, Isao; Asano, Kazuhito; Shikama, Yusuke; Hamasaki, Taisuke; Kanei, Ayako; Suzaki, Harumi.

Affiliation

Suzaki I; Department of Otorhinolaryngology, School of Medicine, Showa University, Tokyo, Japan.

Int J Chron Obstruct Pulmon Dis ; 6: 439-48, 2011.

Article in En | MEDLINE | ID: mdl-22003289

Subject(s)

Bronchi/drug effects; Epithelial Cells/drug effects; Fibroblasts/drug effects; Interleukin-8/metabolism; Lung/drug effects; Muscarinic Antagonists/pharmacology; Scopolamine Derivatives/pharmacology; Adult; Aged; Bronchi/cytology; Bronchi/immunology; Cells, Cultured; Dose-Response Relationship, Drug; Down-Regulation; Enzyme-Linked Immunosorbent Assay; Epithelial Cells/immunology; Female; Fibroblasts/immunology; Humans; Interleukin-8/genetics; Lipopolysaccharides/pharmacology; Lung/cytology; Lung/immunology; Male; Middle Aged; Mitogen-Activated Protein Kinases/antagonists & inhibitors; Mitogen-Activated Protein Kinases/metabolism; NF-kappa B/metabolism; Phosphorylation; Protein Kinase Inhibitors/pharmacology; RNA, Messenger/metabolism; Real-Time Polymerase Chain Reaction; Signal Transduction/drug effects; Tiotropium Bromide

Key words

IL-8; airway cells; in vitro; suppression; tiotropium bromide

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Scopolamine Derivatives / Bronchi / Interleukin-8 / Muscarinic Antagonists / Epithelial Cells / Fibroblasts / Lung Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Int J Chron Obstruct Pulmon Dis Year: 2011 Document type: Article Affiliation country: Japan Country of publication: New Zealand

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