Iron insufficiency compromises motor neurons and their mitochondrial function in Irp2-null mice.

Jeong, Suh Young; Crooks, Daniel R; Wilson-Ollivierre, Hayden; Ghosh, Manik C; Sougrat, Rachid; Lee, Jaekwon; Cooperman, Sharon; Mitchell, James B; Beaumont, Carole; Rouault, Tracey A

Jeong, Suh Young; Crooks, Daniel R; Wilson-Ollivierre, Hayden; Ghosh, Manik C; Sougrat, Rachid; Lee, Jaekwon; Cooperman, Sharon; Mitchell, James B; Beaumont, Carole; Rouault, Tracey A.

Affiliation

Jeong SY; Eunice Kennedy Shriver National Institute of Child Health and Development, National Institutes of Health, Bethesda, Maryland, United States of America.

PLoS One ; 6(10): e25404, 2011.

Article in En | MEDLINE | ID: mdl-22003390

Subject(s)

Gene Deletion; Iron Deficiencies; Iron Regulatory Protein 2/deficiency; Iron Regulatory Protein 2/genetics; Mitochondria/metabolism; Motor Neurons/metabolism; Motor Neurons/pathology; Animals; Apoferritins/biosynthesis; Atrophy/metabolism; Axons/drug effects; Axons/metabolism; Axons/pathology; Biomarkers/metabolism; Brain/drug effects; Brain/metabolism; Brain/pathology; Cyclic N-Oxides/pharmacology; Homeostasis/drug effects; Homeostasis/genetics; Iron/metabolism; Iron Regulatory Protein 1/deficiency; Iron Regulatory Protein 1/metabolism; Mice; Mitochondria/drug effects; Mitochondria/genetics; Mitochondria/pathology; Motor Neurons/drug effects; Oxidative Stress/drug effects; Oxidative Stress/genetics; Spin Labels; Spinal Cord/drug effects; Spinal Cord/metabolism; Spinal Cord/pathology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Gene Deletion / Iron Regulatory Protein 2 / Iron Deficiencies / Mitochondria / Motor Neurons Limits: Animals Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2011 Document type: Article Affiliation country: United States Country of publication: United States

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