Revealing a positive charge patch on a recombinant monoclonal antibody by chemical labeling and mass spectrometry.

Zhang, Liangyi; Lilyestrom, Wayne; Li, Charlene; Scherer, Thomas; van Reis, Robert; Zhang, Boyan

Zhang, Liangyi; Lilyestrom, Wayne; Li, Charlene; Scherer, Thomas; van Reis, Robert; Zhang, Boyan.

Affiliation

Zhang L; Protein Analytical Chemistry, Genentech Inc., South San Francisco, California 94080, United States.

Anal Chem ; 83(22): 8501-8, 2011 Nov 15.

Article in En | MEDLINE | ID: mdl-22004540

Subject(s)

Antibodies, Monoclonal/chemistry; Staining and Labeling/methods; Antibodies, Monoclonal/analysis; Arginine/chemistry; Humans; Lysine/chemistry; Mass Spectrometry; Models, Molecular; Peptide Mapping; Recombinant Proteins/analysis; Recombinant Proteins/chemistry

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Staining and Labeling / Antibodies, Monoclonal Type of study: Prognostic_studies Limits: Humans Language: En Journal: Anal Chem Year: 2011 Document type: Article Affiliation country: United States Country of publication: United States

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