IFN-Î³ promotes muscle damage in the mdx mouse model of Duchenne muscular dystrophy by suppressing M2 macrophage activation and inhibiting muscle cell proliferation.

Villalta, S Armando; Deng, Bo; Rinaldi, Chiara; Wehling-Henricks, Michelle; Tidball, James G

Villalta, S Armando; Deng, Bo; Rinaldi, Chiara; Wehling-Henricks, Michelle; Tidball, James G.

Affiliation

Villalta SA; Molecular, Cellular, and Integrative Physiology Program, University of California, Los Angeles, Los Angeles, CA 90095-1606, USA.

J Immunol ; 187(10): 5419-28, 2011 Nov 15.

Article in En | MEDLINE | ID: mdl-22013114

Subject(s)

Growth Inhibitors/adverse effects; Immunosuppressive Agents/adverse effects; Interferon-gamma/physiology; Macrophage Activation/immunology; Muscle, Skeletal/immunology; Muscle, Skeletal/pathology; Muscular Dystrophy, Duchenne/immunology; Muscular Dystrophy, Duchenne/pathology; Animals; Cells, Cultured; Coculture Techniques; Disease Models, Animal; Growth Inhibitors/deficiency; Growth Inhibitors/physiology; Immunophenotyping; Immunosuppressive Agents/pharmacology; Interferon-gamma/adverse effects; Interferon-gamma/deficiency; Macrophage Activation/genetics; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Inbred mdx; Mice, Knockout; Mice, Transgenic; Muscle, Skeletal/growth & development; Muscular Dystrophy, Duchenne/etiology; Regeneration/genetics; Regeneration/immunology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Interferon-gamma / Muscle, Skeletal / Muscular Dystrophy, Duchenne / Growth Inhibitors / Immunosuppressive Agents / Macrophage Activation Type of study: Etiology_studies / Prognostic_studies Limits: Animals Language: En Journal: J Immunol Year: 2011 Document type: Article Affiliation country: United States Country of publication: United States

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